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1

Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds

Eric M. Guantai, Kanyile Ncokazi, Timothy J. Egan, Jiri Gut, Philip J. Rosenthal, Peter J. Smith, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 575 KB

english, 2010

2

Effects of highly active novel artemisinin–chloroquinoline hybrid compounds on β-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum

Tzu-Shean Feng, Eric M. Guantai, Margo Nell, Constance E.J. van Rensburg, Kanyile Ncokazi, Timothy J. Egan, Heinrich C. Hoppe, Kelly Chibale

Journal:

Biochemical Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.10 MB

english, 2011

3

Reversed Chloroquines Based on the 3,4-Dihydropyrimidin-2(1H)-one Scaffold: Synthesis and Evaluation for Antimalarial, β-Haematin Inhibition, and Cytotoxic Activity

Natasha October, Nicholas D. Watermeyer, Vanessa Yardley, Timothy J. Egan, Kanyile Ncokazi, Kelly Chibale

Journal:

Year:

2008

Language:

english

File:

PDF, 201 KB

english, 2008

4

A colorimetric high-throughput β-hematin inhibition screening assay for use in the search for antimalarial compounds

Kanyile K. Ncokazi, Timothy J. Egan

Journal:

Analytical Biochemistry

Year:

2005

Language:

english

File:

PDF, 562 KB

english, 2005

5

Effects of solvent composition and ionic strength on the interaction of quinoline antimalarials with ferriprotoporphyrin IX

Timothy J. Egan, Kanyile K. Ncokazi

Journal:

Journal of Inorganic Biochemistry

Year:

2004

Language:

english

File:

PDF, 255 KB

english, 2004

6

Quinoline antimalarials decrease the rate of β-hematin formation

Timothy J. Egan, Kanyile K. Ncokazi

Journal:

Journal of Inorganic Biochemistry

Year:

2005

Language:

english

File:

PDF, 328 KB

english, 2005

7

Enone– and Chalcone–Chloroquinoline Hybrid Analogues: In Silico Guided Design, Synthesis, Antiplasmodial Activity, in Vitro Metabolism, and Mechanistic Studies

Guantai, Eric M., Ncokazi, Kanyile, Egan, Timothy J., Gut, Jiri, Rosenthal, Philip J., Bhampidipati, Ravi, Kopinathan, Anitha, Smith, Peter J., Chibale, Kelly

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.02 MB

english, 2011

8

Haemozoin (β-haematin) biomineralization occurs by self-assembly near the lipid/water interface

Timothy J. Egan, Jeff Y-J. Chen, Katherine A. de Villiers, Tebogo E. Mabotha, Kevin J. Naidoo, Kanyile K. Ncokazi, Steven J. Langford, Don McNaughton, Shveta Pandiancherri, Bayden R. Wood

Journal:

Year:

2006

Language:

english

File:

PDF, 339 KB

english, 2006

9

Antiplasmodial, β-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines

Musonda, Chitalu C., Yardley, Vanessa, Carvalho de Souza, Renata C., Ncokazi, Kanyile, Egan, Timothy J., Chibale, Kelly

Journal:

Organic & Biomolecular Chemistry

Year:

2008

Language:

english

File:

PDF, 150 KB

english, 2008

10

Insights into the Role of Heme in the Mechanism of Action of Antimalarials

Combrinck, Jill M., Mabotha, Tebogo E., Ncokazi, Kanyile K., Ambele, Melvin A., Taylor, Dale, Smith, Peter J., Hoppe, Heinrich C., Egan, Timothy J.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.79 MB

english, 2013

11

The Mechanism of β-Hematin Formation in Acetate Solution. Parallels between Hemozoin Formation and Biomineralization Processes †

Egan, Timothy J., Mavuso, Winile W., Ncokazi, Kanyile K.

Journal:

Year:

2001

Language:

english

File:

PDF, 377 KB

english, 2001

12

The Antimalarial Ferroquine: Role of the Metal and Intramolecular Hydrogen Bond in Activity and Resistance

Dubar, Faustine, Egan, Timothy J., Pradines, Bruno, Kuter, David, Ncokazi, Kanyile K., Forge, Delphine, Paul, Jean-François, Pierrot, Christine, Kalamou, Hadidjatou, Khalife, Jamal, Buisine, Eric, Ro

Journal:

ACS Chemical Biology

Year:

2011

Language:

english

File:

PDF, 4.28 MB

english, 2011

13

Crystallization of Synthetic Hemozoin (Beta-Hematin) Nucleated at the Surface of Synthetic Neutral Lipid Bodies

Egan, Timothy J, Hoang, Anh N, Ncokazi, Kanyile K, de Villiers, Katherine A, Wright, David W

Journal:

MRS Proceedings

Year:

2010

Language:

english

File:

PDF, 589 KB

english, 2010